How does naltrexone work?

Naltrexone works by binding to the mu-opioid receptors in the brain, which are part of the brain's reward system. Normally, when someone consumes alcohol or opioids, these substances activate these receptors, leading to feelings of pleasure or euphoria. By blocking these receptors, naltrexone reduces the pleasurable sensations associated with drinking or using opioids. Over time, this makes drinking or using drugs less rewarding and can lead to a decrease in cravings. Naltrexone doesn’t block all forms of pleasure, such as those from food or social interactions, but specifically targets the chemical pathways involved in addiction.