Can I take opioids while on naltrexone?

No, you should not take opioids while on naltrexone. Naltrexone blocks the effects of opioids, so taking opioids while on the medication will prevent them from working as intended, and could result in sudden opioid withdrawal if you’re physically dependent on opioids. This withdrawal can be severe and uncomfortable, so it’s crucial to avoid any opioid medications while taking naltrexone. If you need pain management, your healthcare provider will work with you to find non-opioid alternatives or carefully manage any opioid use if absolutely necessary.